I would go with a Glock G20 10mm, its fairly cheap, very simple to use, light weight, and accurate. It holds 15 rounds a clip which is plent from stopping a home intruder. Of the many hand guns i have shot over the years this was the best feeling and most accurate to me. However if you wanna get some show stopping ability you could always go with the .44 magnum, the most powerful handgun in the world, and would blow your head clean off, you've got to ask yourself one question: Do I feel lucky? Well, do ya, punk?
When i was reading this post and a song came on saying "Did you ever see what a 44. magnum pistol would do to a womens face? I mean it would fucken destroy it just blow her right apart."
Oh man.